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All about cholestasis causes of cholestasis symptoms of cholestasis diagnosis of cholestasis treatment for cholestasis cholestasis of pregnancy causes of cholestasis of pregnancy treatment for cholestasis of pregnancy Articles in liver diseases - cirrhosis of the liver hemochromatosis primary sclerosing cholangitis primary biliary cirrhosis alagille syndrome alpha1-antitrypsin deficiency Crigler-Najjar syndrome hepatitis fatty liver liver transplant Wilson's disease ascites cholestasis jaundice liver encephalopathy liver failure portal hypertension

What's the treatment for cholestasis?

The goal of treatment is to eliminate or control the patient's symptoms. Discontinuing the use of certain drugs can restore

normal liver function, but surgery may be needed to drain or remove obstructions or to widen affected ducts.

Cholestasis often does not respond to medical therapy of any sort. Some reports indicate success in children with chronic cholestatic diseases with the use of ursodeoxycholic acid (20-30 mg/kg/d), which acts to increase bile formation and antagonizes the effect of hydrophobic bile acids on biological membranes. Phenobarbital (5 mg/kg/d) may also be useful in some children with chronic cholestasis. Opiate antagonists can block cholestasis-associated itching.

Rifampin (Rifadin, Rimactane), an antibacterial drug; phenobarbital, a barbiturate anticonvulsant; and other drugs are sometimes prescribed to cleanse the system and eliminate bile salts and other toxic compounds.

Patients who have chronic cholestasis and have trouble digesting fat may have to restrict the amount of fat in their diet and take calcium and water-soluble vitamin supplements. A liver transplant may become necessary if complications occur.

More information on cholestasis

What's cholestasis? - Cholestasis is a condition caused by rapidly developing or chronic interruption in the excretion of bile. Cholestasis is the obstruction of the flow of bile from the gall bladder.
What causes cholestasis? - Cholestasis is related to a transient injury. Cholestasis can also be the result of liver diseases such as sclerosing cholangitis, biliary atresia, primary biliary cirrhosis, and others.
What're the symptoms of cholestasis? - Symptoms of both intrahepatic and extrahepatic cholestasis include a yellow discoloration of the skin (jaundice), dark urine, and pale stools.
How is cholestasis diagnosed? - A history of hepatitis or heavy drinking, recent use of certain drugs, and symptoms like ascites and splenomegaly suggest intrahepatic cholestasis.
What's the treatment for cholestasis? - The goal of treatment for cholestasis is to eliminate or control the patient's symptoms. Cholestasis often does not respond to medical therapy of any sort.
What is cholestasis of pregnancy? - Cholestasis of pregnancy is a condition in which the normal flow of bile in the gallbladder is affected by the high amounts of pregnancy hormones.
What causes cholestasis of pregnancy? - Pregnancy hormones affect gallbladder function, resulting in slowing or stopping of the flow of bile.
What's the treatment for cholestasis of pregnancy? - The goals of treating cholestasis of pregnancy are to relieve the itching and prevent complications.
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